The University of Uyo was founded in 1991 by the Federal Government of Nigeria.

The University is located in the heart of Uyo, capital of Akwa Ibom State, Nigeria. Uyo is accessible by road and there are two International Airport within 100km radius – the Margaret Ekpo International Airport, Calabar, Cross River State and the Ibom International Airport in Uyo, Akwa Ibom State.

The University runs a multi-campus system namely: The Main Campus, the Town Campus and Annex Campus, the College of Health Sciences Campus and the Ime Umanah Campus.